The mealybug is a polyphagous sucking pest which causes vast cotton destruction resulting in 100% yield loss. Trial work on the evaluation of sanitary, biological and chemical control techniques for the white mealybug in cotton was initiated in 2016/17 to 2019/20. Trials laid out in a Randomised Complete Block Design (RCBD) with six treatments replicated four times, were set up at Chizvirizvi, Masakadza, Dande, Muzarabani, Tokwane and Matikwa in 2016/17 to 2019/20. The treatments used in the study were: (1) No control of mealybugs only weeding to keep cotton weed free from planting to harvest, (2) Larvin 375SC at 1.250 litres/ha, (3) Cabaryl 85WP at 1.470kg/ha, (4) Cartap hydrochloride 50SP at 1 kg/ha, (5) Marshal 25EC at 0.250 litres/ha with 1ml Cooking oil, (6) Biological control with locally found predators (Coccinellid beetles, larva and wasps). Measurements were mealybug counts. The square root transformation of count + 3/8 was used on all data not following a normal distribution curve. Significant treatment means (p < 0.05) were separated using Fisher‘s Protected LSD test. Larvin 375 SC, Carbaryl 85 WP, and Cartap hydrochloride 50 SP gave good control of the mealybug. The three insecticides were recommended for mealybug control at the rates: Larvin 375 SC 1.250 l/ha (468.75g ai/ha), Carbaryl 85wp 1.470kg/ha (1250g ai/ha) and Cartap hydrochloride 50sp at 1kg/ha (500g ai/ha).