Chemical fertilizers are becoming more and more necessary in developing countries like India where they damage the environment, water, and human health, harm the soil’s micro-flora and fauna, and also increase production costs. Finding a safer alternative for these harmful compounds is, therefore, essential. The diverse collection of plant growth-promoting rhizobacteria (PGPR) quickly colonizes the rhizosphere and offers direct or indirect protection to agricultural plants. In addition to significantly increasing the seed germination rate, PGPR treatment offered protection against harmful microbes. It has been shown that PGPR significantly increased several crop’s yields and their capacity to absorb nutrients and water. PGPR exhibits encouraging outcomes by developing a symbiotic interaction with other beneficial microorganisms, boosting nitrogen fixation, and expanding the supply of primary, secondary, and micro-nutrients. The present review highlights the usefulness of PGPR as a biofertilizer for a safe and effective substitute for chemical fertilizers in environmentally responsible and sustainable agriculture.