Honey, long revered for its therapeutic and nutritional properties, is a natural substance with a complex composition that includes a variety of sugars, vitamins, minerals, amino acids, and bioactive compounds. This review critically examines the nutritional profile of honey, shedding light on its profound implications for human health and the prevention of chronic diseases. The bioactive compounds in honey, particularly its antioxidants and phenolics, play a pivotal role in its antimicrobial, anti-inflammatory, and immune-boosting effects. Furthermore, honey’s potential to manage and mitigate chronic conditions such as cardiovascular diseases, diabetes, and cancer is explored in depth. The review also addresses the significant variability in honey’s composition, influenced by its botanical and geographical origins, and discusses how these factors impact its health benefits. Ultimately, this review highlights honey’s value as a functional food and its potential role in modern preventive medicine, advocating for further research to fully unlock its health-promoting properties.