A global phenomenon that has bedevilled humanity overtime is food insecurity. This situation can be reverse by adopting agricultural innovative techniques. Despite the utilisation of agricultural innovative techniques, food production challenges have become the new status quo on the eastern slope of Mount Cameroon. This study analysed food production challenges and the utilisation of agricultural innovative techniques on the eastern slope of Mount Cameroon.. A mixed research design that incorporates both qualitative and quantitative techniques was utilized. Through a simple random sampling technique, 200 household farmers were selected within the eastern slope of Mount Cameroon to administer questionnaire. Also, through surveys, interviews, and direct field observations, data were collected and complemented with secondary sources like magazines, public-related articles, offline and online libraries and grey literatures on food production and agricultural techniques. These data were analysed using inferential and descriptive statistical techniques in order to correlate the effect of the utilisation of agricultural innovative techniques on food security. Results revealed that farmers cultivate different crop species with dominance of maize (50%) and 28% vegetables. 57% of farmers’ perceptions indicated that farm production remains very low, due to over-cultivation of farmlands, and poor application of chemical fertilizers.,. In responding to this challenge, farmers have adopted innovative techniques such as chemical fertilizer (50%), organic manure (30%), and improved seeds (15%) which have fairly improved agricultural production. However, the continuous decline in food production amidst innovative techniques is explained by financial challenges (36%), limited farmers union and cooperative societies (25%), limited knowledge (21%), and geographical factors (17%). The study recommends that objective and holistic innovative measures such as agroforestry, careful application of chemical fertilizer, improved seeds, organic farming, irrigation practice, improve agricultural infrastructures and institutions must be encourage for sustainable agricultural production to thrive.